Do you like this page?



Views of this page
50

Views of the site
10520


Please help share my site. Thank you!







Systematic and quantitative view of the antiviral arsenal of prokaryotes- Easy Microbial Genomics

Home > Paper Highlights >  Systematic and quantitative view of the antiviral arsenal of prokaryotes

Systematic and quantitative view of the antiviral arsenal of prokaryotes

Posted May 9, 2022

Prokaryotes have evolved multiple lines of defense against viruses. As of 2018, only a few prokaryotic antiviral systems are listed, including the CRISPR-Cas system, restriction modification (RM), and miscarriage infection (Abi). In 2018, a groundbreaking research revealed the existence of 10 new antiviral defense systems, marking the beginning of a new era of discovery. Since then, dozens of new systems have been unearthed.

Bacteria and archaea have developed multiple antiviral mechanisms, and genomic evidence suggests that some of these antiviral systems coexist in the same strain. However, there is a limitation of tools for us to detect them.

A research group of Dr. Jean Cury from Université Paris-Saclay and Dr. Aude Bernheim from Université de Paris have developed the DefenseFinder, a tool for automatically detecting known antiviral systems in the genome of prokaryotes. Analyzing the genomes of 21,000 fully sequenced prokaryotes using DefenseFinder revealed that antiviral strategies vary widely by phyla, species, and strain. Changes in the composition of antiviral systems correlate with genomic size, viral threats, and lifestyle characteristics. DefenseFinder facilitates extensive genomic analysis of antiviral defense systems and study of host-viral interactions in prokaryotes.


DefenseFinder, a tool to detect all known prokaryotic antiviral systems

image source: Nat Commun

Reference

Tesson F, Hervé A, Mordret E, Touchon M, d'Humières C, Cury J, Bernheim A. Systematic and quantitative view of the antiviral arsenal of prokaryotes. Nat Commun. 2022 May 10;13(1):2561. doi: 10.1038/s41467-022-30269-9. PMID: 35538097.